Study on Efficacy of rhBMP-2 for Extraction Sockets Preservation with Bone Wall Defect
Objective:To evaluate the efficacy of recombinant human bone morphogenetic protein-2(rhBMP-2)for alveolar ridge preservation with bone wall defect.Methods:From February 2019 to January 2023,142 eligible pa-tients were randomly divided into group A using rhBMP-2 + collagen sponge to fill the extraction sockets,group B using collagen sponge alone,and group C using no grafts.The implant surgery was carried out at 18 and 24 weeks after tooth extraction,and three groups were divided into group A1,A2;B1,B2;and C1,C2.Maximum meso-distal and buccal-lingual diameter(L,W)and depth(H)of alveolar crest defect were measured in cases of alveolar ridge bone defects found during implant surgery,and V values were calculated(V=L×W×H).Bone blocks of im-plant sockets were obtained for histological evaluation in cases without alveolar bone defects.Results:The frequency of alveolar ridge bone defects in group A1 and A2 were 0.32 and 0.14;in group B1 and B2 were 0.75 and 0.43;and in group C1 and C2 were 0.72 and 0.37,respectively.There were significant differences between group A1 and B1;between group A2 and B2;between group A1 and C1,and between group A2 and C2 in V value(P<0.05).There were significant differences between group A1 and B1 and between group A1 and C1 in new bone percentage(P<0.05).Conclusion:The use of rhBMP-2 for alveolar ridge preservation with bone wall defect can shorten the time of osteogenesis(18 weeks),reduce the frequency of erratic healing,and provide a favorable bone condition for subse-quent implantation.
alveolar ridge preservationrecombinant human bone morphogenetic protein-2oral implantology
万方数据
维普
