脱落细胞DNA定量分析技术动态监测口腔扁平苔藓伴上皮异常增生病情及光动力治疗1例
Dynamic Monitoring of Oral Lichen Planus with Epithelial Dysplasia and Effect of Photodynamic Therapy Using DNA Content Analysis of Exfoliated Cells:A Case Report
董冰洁 1刘泽燏 1李婷 1周刚 1卢锐1
作者信息
- 1. 口颌系统重建与再生全国重点实验室,口腔生物医学教育部重点实验室,口腔医学湖北省重点实验室,武汉大学口腔医(学)院 湖北武汉 430079;武汉大学口腔医院口腔黏膜科 湖北武汉 430079
- 折叠
摘要
口腔扁平苔藓是一种临床上常见的慢性炎性口腔黏膜病,具有癌变风险,临床上应积极干预并随访监测.光动力治疗具有微创、有效、选择性好以及可重复性高等优势,在治疗口腔扁平苔藓中已显现出良好疗效,但其疗效评估方法仍然存在局限性.脱落细胞DNA定量分析技术是一种无创辅助检查手段,可用于口腔潜在恶性疾患癌变及口腔癌的早筛早诊.本文报道1例采用脱落细胞DNA定量分析技术动态监测口腔扁平苔藓癌变风险及光动力治疗疗效的诊疗过程,以期为建立口腔扁平苔藓伴上皮异常增生的精准微创诊疗体系提供参考.
Abstract
Oral lichen planus(OLP)is a common chronic inflammatory oral mucosal disease with a risk of malig-nant transformation,which required active intervention and close follow-up and monitoring.Photodynamic therapy(PDT)has been widely used in the treatment of OLP due to its advantages of minimally invasive,effective,good selectivity,and repeatability.However,there are still limitations in the efficacy evaluation approaches of PDT for OLP.DNA quantitative analysis of exfoliated cells is a non-invasive auxiliary examination method,which can be used for the early screening and diagnosis of the malignancy of oral potentially malignant disorders and oral cancer.Here we reported a case of OLP with epithelial dysplasia using DNA content analysis of exfoliated cells to dynami-cally monitor the risk of malignancy and the effect of PDT.The aim of this report is to provide a reference for estab-lishing the precise and minimally invasive diagnosis and treatment of OLP with epithelial dysplasia.
关键词
脱落细胞DNA定量分析/口腔扁平苔藓/上皮异常增生/光动力治疗Key words
DNA content analysis of exfoliated cells/oral lichen planus/epithelial dysplasia/photodynamic therapy引用本文复制引用
基金项目
基项项目武汉大学护理专项科研培育基金(600400018)
出版年
2024
NETL
NSTL
万方数据