药物相关性颌骨坏死(medication-related osteonecrosis of the jaw,MRONJ)及放射性颌骨坏死(osteora-dionecrosis of the jaw,ORNJ)是两种常见的难治性医源性颌骨坏死.随着骨组织工程的迅猛发展,将生物材料负载干细胞所制成的干细胞复合物,用于对MRONJ及ORNJ的预防和治疗成为本领域研究的重点和热点.本文通过对干细胞复合物防治MRONJ和ORNJ的相关研究进行回顾,阐述干细胞复合物对MRONJ 及 ORNJ的防治效果和影响因素,分析该技术有待探究的问题,以期为进一步研究指明方向,为临床应用提供依据.
Abstract
Medication-related osteonecrosis of the jaw(MRONJ)and osteoradionecrosis of the jaw(ORNJ)are two common and refractory iatrogenic osteonecrosis of the jaw,which pose significant clinical challenges.Given the swift progress in bone tissue engineering,the spotlight has shifted to stem cell composites comprised of biomaterials loaded with stem cells and their application in the prevention and treatment of MRONJ and ORNJ.This article re-views the pertinent researches on the prevention and treatment of MRONJ and ORNJ using stem cell composites.It elucidates the effects and influencing factors of stem cell composites in the context of preventing and treating MRONJ and ORNJ.Additionally,the article conducts an analysis of the unresolved issues within this technology,aiming to identify directions for future research endeavors and offering insights for clinical applications.
关键词
颌骨坏死/干细胞/干细胞复合材料
Key words
osteonecrosis of the jaw/stem cell/stem cell composite
维普
万方数据