Research Progress on Regulation of Macrophages Involvement in Periodontal Disease by Lactate/Lactation Modifica-tion
Lactate,as the end product of glycolysis,plays an important role in terms of energy sources,signaling molecules,and immune adjustment.Lactylation(Kla)is a newly discovered method to translate proteins based on lactate and lithium acid residues that are closely associated with a variety of inflammatory diseases.Peritoneal patho-gens are the main cause of periodontitis(PD),which is an immune inflammation caused by the host's immune re-sponse.According to recent research,the increase of lactate content in periodontitis microenvironment leads to the increase of lactylation level,which can eventually slow down the spread of inflammation and help tissue repair by changing the polarization of macrophages and promoting the differentiation of bone cell.Therefore,this paper re-views the research progress of lactate/lactylation in regulating macrophage function and inflammatory diseases such as periodontitis in recent years,so as to provide reference for follow-up research and treatment of periodontitis.
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