Chlorhexidine(CHX)is the most widely applicated biocide for clinical surface disinfection,however,there is a lack of regulations on its usage.The long-term and extensive utilization of CHX has led to the reduced susceptibility against CHX and cross-resistance towards an array of critical antibiotics in clinical isolates of multiple essential pathogens related to nosocomial infections.However,the potential resistance risk in oral bacteria has been overlooked even though CHX has been applied as the gold standard in dentistry for over 50 years.Hence,the cur-rent review aims to summarize the evidence of the reduced susceptibility to CHX in oral bacteria and elucidate the relative mechanisms to raise the concern about its potential risk in dental practice.
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