Oral squamous cell carcinoma(OSCC)is a common malignant oral tumor with a tendency for metasta-sis,recurrence,and drug resistance.Current research on its mechanisms is insufficient.Single-cell sequencing and the spatial transcriptome technology can obtain transcriptome information at the single-cell level,enabling more in-depth research on cell populations,functions,changes,and communication.This paper provides a comprehensive summary of the application of single-cell sequencing technology in OSCC research areas such as cell typing,tumor microenvironment,tumor invasion and metastasis,therapeutic targets and prognostic markers,immune-targeted therapy,and intratumoral microbiota.It also points out the current deficiencies in research and suggests directions for future improvements.
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