Head and neck squamous cell carcinoma(HNSCC)is the most prevalent cancer of the head and neck which exhibits significant heterogeneity,and its etiology remains incompletely understood.Single-cell transcriptome sequencing enables unbiased,high-throughput and high-resolution transcriptome sequencing to obtain relevant data and perform information analysis at the single-cell level,which has become a powerful tool to understand the molecular mechanisms of the development of HNSCC and to develop new strategies for prevention and treatment.This review summarized the important study and latest achievements of single-cell transcriptome sequencing in the characterization of tumor microenvironment,tumor invasion and metastasis,human papilloma virus(HPV+)and HPV infection of HNSCC,and immunotherapy,aiming to provide new ideas for the research,diagnosis,and treatment of HNSCC.
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