Orthodontic tooth movement is a key step in clinical orthodontic treatment.By applying appropriate orthodontic forces to the teeth,these forces are transmitted to the periodontium,causing adaptive remodeling of the surrounding soft and hard tissues.The transient receptor potential vanilloid 4 channel(TRPV4)is a mechanically sensitive calcium channel protein with multiple functions and complex mechanisms.It plays an important role in the transmission of mechanical forces,inflammatory responses,and other aspects.In recent years,researchers have found that the TRPV4 channel is also involved in orthodontic tooth movement.This article provides a review of the role of the TRPV4 channel in orthodontic tooth movement,aiming to provide a foundation and theoretical basis for clinical orthodontic treatment of tooth movement.
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