Nowadays,clear aligner technique is increasingly used in tooth extraction cases.During the retraction of anterior teeth and space closure,lingual tipping and extrusion of incisors and mesial tipping of posterior teeth may occur,a phenomenon known as the roller-coaster effect.Therefore,there is a specific difference between actual tooth movement and virtual tooth movement.Previous research showed that the actual values of the mesial movement and intrusion of the maxillary molars were higher than the designed values,and the crowns exhibited mesial tipping after orthodontic treatment.This was mainly related to the loss of molar anchorage and the'occlusal pad effect'of clear aligners.Canines and incisors often showed distal tipping,lingual tipping and intrusion after treatment.The roller-coaster effect can be prevented by preparing the anchorage of the molars,overcorrection design of the torque and intrusion of anterior teeth,the correct attachment design,and the rational application of micro-implants.Currently,most research on clear aligner extraction cases focus on the three-dimensional movement and efficiency of posterior teeth,canines and anterior teeth,as well as how to avoid the roller-coaster effect.This paper mainly summarizes the three-dimensional movement and the treatment of molars,canines,and incisors in tooth extraction cases with clear aligner,providing some ideas and clinical references for clinical practice.