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合成生物学的哲学挑战

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作为一门新兴技术科学,合成生物学引起的哲学挑战包括:本体论层面,合成生命被认为打破人工与自然、生命与机器的界限;认识论层面,合成生物学"建物致知"被认为颠覆传统的科学认识论;方法论层面,科学、技术与工程的融合加速科学知识的增长和应用,被认为实现生物学的范式转变.然而,关于构成挑战的观点难以得到科学事实和理性分析的支持:本体论层面,当前合成生命本质上仍是对自然生命的复制,以人工和自然、生命与机器的二分难以确定未来合成生命的本体;认识论层面,"建物致知"没有脱离传统认识论基础,而是为获取新的生命知识拓展了途径;方法论层面,合成生物学中工程范式没有取代物理范式,两种范式的融合更符合当前与未来生物学发展的实际和要求.
Philosophical Challenges of Synthetic Biology
As an emerging technological science with the most subversive and intersecting characteristics in the 21st century,synthetic biology poses philosophical challenges,i.e.,at the ontological level,synthetic life is considered to break the boundary between artificial and nature,life and machine;at the epistemological level,the"Build life to understand it"of synthetic biology is considered to subvert the traditional scientific epistemology;at the methodo-logical level,the integration of science,technology and engineering has accelerated the growth and application of scientific knowledge and is considered to have achieved a paradigm shift in biology.However,the view of the chal-lenge is difficult to be supported by scientific facts and rational analysis:at the ontological level,the current syn-thetic life is still essentially a copy of natural life,and it is difficult to determine the ontology of future synthetic life based on the dichotomy of artificial and natural,life and machine;at the epistemological level,"Build life to un-derstand it"does not break away from the traditional epistemological basis,but expands the way to acquire new life knowledge;at the methodological level,the engineering paradigm has not replaced the physical paradigm in syn-thetic biology,and the integration of the two paradigms is more in line with the reality and requirements of the cur-rent and future development of life science.

synthetic biologyontologyepistemologymethodologyparadigm

冀朋、雷瑞鹏、胡翌霖

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汕头大学马克思主义学院,广东汕头 515000

电子科技大学科技伦理治理研究中心,成都 610000

清华大学科学史系,北京 100080

合成生物学 本体论 认识论 方法论 范式

国家重点研发计划广东省哲学社会科学规划项目

2018YFA0902400GD22YZX02

2024

科学技术哲学研究
山西大学 山西省自然辩证法研究会

科学技术哲学研究

CSSCICHSSCD北大核心
影响因子:0.299
ISSN:1674-7062
年,卷(期):2024.41(3)
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