To Explore the Drug Syndrome Types and Mechanism of Perivascular Disease Based on Hidden Structure and Network Pharmacology
To explore the drug syndrome type and feasibility of TCM in the treatment of panvascular diseases by computer technolo-gy,and to provide objective reference for clinical treatment and new drug research and development.Chinese patent medicines for vas-cular diseases in Pharmacopoeia of the People's Republic of China(2020 edition)were retrieved and the data were analyzed.Implicit structure analysis was performed by Lantern 5.0 to predict the network pharmacology and verify the molecular docking of Z5 group drugs.79 related patent Chinese medicines were obtained,involving 156 traditional Chinese medicines,among which the high-frequen-cy traditional Chinese medicines were salvia miltiorrhiza,Chuanxiongxiong,notoginseng,etc.,with the main effect of tonifying defi-ciency and promoting blood circulation and removing blood stasis,the most of warm drugs,with the main taste of sweet and bitter,en-tering the liver and heart channel.Through the analysis of hidden structure,it is inferred that there are 5 kinds of common witness syn-dromes:Qi deficiency and blood stasis,phlegm stasis blocking collaterals,Yin deficiency and blood stasis.It can be seen that the overall pan vascular disease is caused by deficiency,deficiency and insufficiency,qi deficiency and blood stasis.Clinical treatment is mainly to promote blood stasis,with the syndrome with supplementing Qi and qi,warming Yang and nourishing Yin,eliminating phlegm and other treatment methods.Through network pharmacology and molecular docking,it was found that Z5 drugs may activate the role of fluid shear stress and atherosclerosis,AGE-RAGE signaling pathway in diabetic complications,blood lipid and atherosclero-sis signaling pathway through the main active ingredients quercetin,baicalein and kaferol,and act on TNF,AKT1,PTGS2 and other targets.It interferes with inflammation,cell proliferation and apoptosis,lipid metabolism and other processes to play an anti-atheroscle-rosis role,so as to treat panvascular disease,indicating that there is a certain effectiveness and possibility in exploring the treatment of diseases through computer technology analysis of existing data.
hidden structureperivascular diseasetraditional Chinese medicineatherosclerosismolecular docking
NETL
NSTL
万方数据
