Size and structure effects in the nanotoxic response of nanomaterials
The biological effects and safety of nanomaterials are of particular significance in nanoscience, and are a key issue in the application of nanotechnology. Nanotechnology therefore needs breakthroughs in these two areas. First, precisely controllable and repeatable manufacturing processes must be developed on an industrial scale. Second, nanosafety knowledge and methodology must be developed, and safety assessment of nanoproducts must be given a regulatory framework. To prioritize the development of new technologies and to provide new products for the global market, the development of "safe products" must be considered of equal importance to the development of "leading technology". This has become a national strategy in many countries, and it is why nanotoxicology has quickly become a scientific discipline in the past five years. It is now known that the toxicological effects of nanomaterials are related to many of their properties. In this article, we focus primarily on two of the most important ones: nanosize and nanostructure. The dose-effects on nanotoxic responses are also briefly discussed. Particular focus is given to the differences in dose-effect relationships in traditional toxicology and nanotoxicology. Finally, we discuss the need for future research. Specifically, we identify the most important research topics, which urgently need to be understood, because of the rapid development of nanotechnology and its applications.
NETL
NSTL
万方数据
维普
