本研究旨在分析SpO2/HCT比值作为高原习服性评估指标对高原习服与适应的预测价值.收集了西藏自治区某医院2347名接受常规体检的患者体检报告,并由高原病研究专家根据患者体检报告和问诊结果,将患者分为高原习服性组和高原不习服组.采用SpO2/HCT指标作为高原习服性评估指标,并对两组进行比较.同时,分析高原习服性评估指标与慢性高原病(chronic mountain sickness,CMS)之间的相关性.使用受试者工作特征(receiver operat-ing characteristic,ROC)曲线下面积(area under the curve,AUC)来评估高原习服性评估指标对高原习服良好与不良人群的诊断效能.通过SpO2/HCT指标与世居者生理生化指标的关联,证明了SpO2/HCT比值评估的准确性.本研究确认,SpO2/HCT指标(altitude acclimatization/adaptation index,AAI)能够有效评估个体在高原的习服和适应水平.AAI=1.7228被确定为高原习服和适应的临界值,小于1.7228表示习服和适应不良,而大于等于1.7228表示习服和适应良好.AAI适用于高海拔移居者和世居者的高原习服或适应程度评估.
Evaluation model of acclimatization and adaptation at high altitude
The research aim was to delve into the nuanced realm of high-altitude acclimatization and adaptation,focusing primarily on the predictive efficacy of the SpO2/HCT ratio as a key indicator.Drawing from a robust dataset comprising medical examination reports from 2347 patients undergoing routine check-ups at a hospital situated in the Xizang Autonomous Region,researchers sought to unravel the intricate dynamics of physiological adjustments at elevated altitudes.High-altitude medicine experts,armed with their specialized knowledge,meticulously categorized the diverse patient pool into distinct groups based on acclimatization status.This demarcation led to the identification of two cohorts:Individuals adept at acclimating to high altitudes and those grappling with challenges in adaptation.The SpO2/HCT ratio played a pivotal role as the chosen metric for assessing acclimatization,setting the stage for a comparative analysis between the two groups.Simultaneously,the correlation between the selected acclimatization indicator,the SpO2/HCT ratio,and the prevalence of chronic mountain sickness(CMS),was explored.This multifaceted approach aimed to unravel potential connections between acclimatization levels and the manifestation of chronic health issues in high-altitude environments.To bolster the robustness of the findings,the researchers employed such sophisticated analytical tools as the receiver operating characteristic(ROC)curve analysis and the area under the curve(AUC)calculator.These methodologies were harnessed to scrutinize the diagnostic performance of the SpO2/HCT ratio in discerning individuals with varying degrees of acclimatization to the challenges posed by high altitudes.Further fortifying the study's foundation,an in-depth exploration of the association between the SpO2/HCT ratio and the physiological and biochemical indicators of long-term high-altitude residents was conducted.The aim of this holistic approach was to validate the accuracy of the SpO2/HCT ratio as a reliable assessment tool for acclimatization.The culmination of these efforts yielded a noteworthy revelation—the identification of an altitude acclimatization/adaptation index(AAI),with a critical threshold set at 1.7228.Values falling below this threshold signaled poor acclimatization and adaptation,while those equal to or surpassing 1.7228 indicated a commendable state of acclimatization.This quantitative benchmark provided a tangible measure for evaluating and categorizing individuals based on their acclimatization and adaptation levels in high-altitude environments.Intriguingly,the study's outcomes unveiled a landscape where approximately 70％of individuals demonstrated commendable acclimatization to the challenges posed by high altitudes,contrasting with the remaining 30％who exhibited suboptimal acclimatization.The practical applicability of the AAI extended beyond its initial scope,proving effective in assessing the acclimatization or adaptation levels of both high-altitude migrants and long-term residents.In essence,the study findings contribute substantively to the understanding of high-altitude acclimatization and adaptation,offering a comprehensive framework anchored in empirical data and analytical rigor.The delineation of the AAI adds a practical dimension,empowering medical practitioners to assess and address acclimatization challenges for diverse populations navigating high-altitude environments.
万方数据
维普
