Progress in research on serum cytokines and the efficacy of PD-1 inhibitors in non-small cell lung cancer
Cytokines produced by programmed death-1/(PD-1)programmed death ligand-1 signaling pathway inhibitors that activate the immune system play a key role in the process of anti-tumor cells.The aim of this study was to review recent studies on the correlation between serum cytokine expression levels and clinical benefits in patients with non-small cell lung cancer treated with programmed death-1 inhibitors,and to reveal the changes in cytokine levels such as interleukin-6,interleukin-8,tumor necrosis factor,interferon and inter-leukin-17A before and after PD-1 treatment in patients with non-small cell lung cancer.It is of great clinical value to find economic and convenient biomarkers for the efficacy of PD-1 inhibitors.