Research progress in biomarkers of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis has poor prognosis and high mortality,and if not treated in time,the median survival period is only 2～3 years after diagnosis.The early symptoms of idiopathic pulmonary fibrosis patients are not obvious,and the diagnosis is often in the mid to late stage of the disease,which seriously affects the prognosis.Therefore,early diagnosis and treatment are particularly important.Biomarkers can play a role in assisting diagnosis,evaluating the condition and predicting prognosis.The paper summarized some of the currently identified biomarkers of idiopathic pulmonary fibrosis from three aspects:alveolar epithelial cell dysfunction,extracellular matrix remodeling and fibrosis and immune dysfunction based on the patho-genesis of idiopathic pulmonary fibrosis,with the hope of providing assistance for the early diagnosis and treatment of idiopathic pulmonary fibrosis and improving prognosis.
国家科技期刊平台
NSTL
万方数据
