Feasibility of pericarotid fat density in predicting intracranial arterial plaque vulnerability
Objective To investigate the correlation of pericarotid fat density with the different types of carotid plaque and the vulnerability of intracranial plaques.Methods Data of 90 patients who were diagnosed of carotid artery atherosclerotic plaque and had undergone carotid artery computed tomography angiography and high resolution vascular wall magnetic resonance imaging were retrospectively analyzed.Carotid plaques were divided into a calcified plaque group(n=22),mixed plaque group(n=23)and non-calcified plaque group(n=45)according to plaque composition on carotid artery computed tomography angiography.A total of 49 patients with ipsilateral intracranial artery plaque were screened from the mixed plaque group and non-calcified plaque group with more severe inflammation of perivascular adipose tissue,and the intracranial artery plaques were divided into a vulnerable plaque group(n=36)and stable plaque group(n=13)according to high resolution vascular wall magnetic resonance imaging.Pericarotid fat density was identified and measured using a combination of Perivascular Fat Analysis Tool software and manual profiling.Independent sample t test,one-way anova,Mann-Whitney U test,Kruskal-Wallis test and Chi-square test were used to compare the differences between the groups.A receiver operating characteristic curve analysis model was plotted to assess the vulnerability of intracranial plaque.Results The pericarotid fat density of calcified plaque,mixed plaque and non-calcified plaque groups were-53.03[-46.02,-56.12],-43.18[-39.30,-46.07],and-42.88[-39.86,-47.29],respectively.Compared with the calcified plaque group,the pericarotid fat densi-ty in the non-calcified plaque group and mixed plaque group were higher,and the difference was statistically significant(P<0.001).Pericarotid fat density(P=0.003,OR=1.165,95%CI:[1.054,1.287]),as an independent risk factor for vulnerable intracranial plaque,had a good predictive value for the vulnerability of intracranial arterial plaque,with the area under the curve being 0.786,and sensitivity and specificity being 91.67%and 61.54%,respectively.Conclusion Pericarotid fat density is an effective marker for predicting the vulnerability of different types of carotid artery plaque and intracranial artery plaque,and can provide support for imaging diagnosis.
国家科技期刊平台
NSTL
万方数据
