Association between peripheral blood inflammation index and axillary lymph node metastasis of breast cancer
Objective To evaluate the associations between peripheral blood inflammation-related indices and axillary lymph node metastasis of breast cancer.Methods Clinical data were retrospectively collected of 328 patients with first diagnosis of invasive breast cancer in the Second Hospital of Lanzhou University from Janu-ary 2018 to August 2023.Various peripheral blood inflammation indices were calculated and the association between each index and axillary lymph node metastasis analysed.Results Univariate analysis showed that the differences in body mass index,tumor diameter,carcinoembryonic antigen,carcinoembryonic antigen 125,systemic inflammatory response index and pan-immunoinflammatory values were statistically significant between axillary and non-axillary lymph node metastasis groups(P<0.05).Multifactorial analysis revealed that tumor diameter,pan-immune inflammation value,systemic inflammatory response index,body mass index,histological grade Ⅲ and carcinoembryonic antigen 125 were independent risk factors for axillary lymph node metastasis.The area under the curve for the pan-immune inflammation value of a subject's operating charac-teristic curve was 0.634,with an optimal threshold value of 110.37.The area under the curve for the systemic inflammatory response index was 0.639,with an optimal threshold value of 0.554.Conclusion Pan-immune inflammation value and systemic inflammation response indices are associated with,and can be potential predictors of,axillary lymph node metastasis in invasive breast cancer.
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