微RNA在糖尿病肾病中的研究进展
Research progress of microRNA in diabetic kidney disease
王佩雯 1王俭勤2
作者信息
- 1. 兰州大学 第二临床医学院,甘肃 兰州 730030
- 2. 兰州大学第二医院 肾病科,甘肃 兰州 730030
- 折叠
摘要
糖尿病肾病(DKD)作为糖尿病最常见的微血管并发症之一,已经成为导致终末期肾病的重要原因之一.微RNA(miRNA)是长度为19～25个碱基对的短链非编码RNA,其可与靶基因mRNA的3'非翻译区结合,参与下游信号分子的表观遗传调控.研究表明miRNA可与DKD的发生发展密切相关,本文就miRNA与DKD之间的关系及其研究进展作一综述,以期为DKD的预防、诊断、治疗提供参考.
Abstract
Diabetic kidney disease(DKD)as one of the most common microvascular complications of diabe-tes,has become an important cause of end-stage renal disease.MicroRNA(miRNA)is short non-coding RNA with 19～25 base pairs in length that bind to the 3'untranslated region of target mRNA and participate in the epigenetic regulation of downstream signaling molecules.Studies have shown that miRNA can participate in the occurrence and development of DKD and have important value for the prevention,early diagnosis and disease assessment of DKD.In this paper,the relationship between miRNA and DKD and the research prog-ress are reviewed in order to provide reference for the prevention,diagnosis and treatment of DKD.
关键词
微RNA/糖尿病肾病/纤维化/炎症/诊断/靶向治疗Key words
microRNA/diabetic kidney disease/fibrosis/inflammation/diagnosis/targeted therapy引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据