杏仁核对焦虑样睡眠障碍的调控
Role of amygdala in the regulation of anxiety-like sleep disorders
解俊樊 1赵雪琪 1高进贤 1任艳丽 1杨兴文 1邵玉峰 1侯一平1
作者信息
- 1. 兰州大学 基础医学院 神经科学研究所,人体解剖与组织胚胎学教研室,甘肃省新药临床前重点实验室,甘肃 兰州 730000
- 折叠
摘要
焦虑症常与睡眠障碍共存且相互作用,一方面睡眠障碍可引起焦虑,另一方面焦虑患者常出现失眠、睡眠片段化等焦虑样睡眠改变.基底外侧杏仁核和中央杏仁核与脑内多个睡眠-觉醒调控核团存在纤维联系,是调控焦虑样行为与睡眠的关键核团.本研究总结杏仁核解剖结构、纤维联系,以及杏仁核调节焦虑样行为与睡眠障碍的作用机制与神经环路,对进一步理解睡眠与焦虑相互作用的潜在机制具有重要意义,为临床治疗焦虑症和睡眠障碍提供理论基础.
Abstract
Anxiety and sleep disorder are related to each other in a bidirectional way;generally,sleep disor-ders cause anxiety and people suffering from anxiety disorders experience insomnia and sleep fragmentation.The basolateral and central amygdala project to the nuclei involved in the regulation of sleep-wake states,thus playing a key role in regulating anxiety-like behavior and sleep disturbance.In this review,we summarized the anatomic structure and fiber connections of amygdalae,and their mechanisms and neural circuits that act on anxiety-like behavior and sleep disturbance so as to provide new insight into the interaction between anxiety and sleep,and come up with fundamental theories for anxiety and sleep disorder treatment.
关键词
焦虑/睡眠-觉醒时相/杏仁核/睡眠障碍/快动眼睡眠/非快动眼睡眠Key words
anxiety/sleep-wake state/amygdala/sleep disorder/rapid eye movement sleep/non-rapid eye movement sleep引用本文复制引用
基金项目
国家自然科学基金(82001396)
甘肃省自然科学基金(20JR5RA228)
出版年
2024
国家科技期刊平台
NSTL
万方数据