Advances in the study of the cytotoxicity of eremophilane sesquiterpene compounds in Ligularia Cass.(Asteraceae)
Eremophilane sesquiterpene is a double-ring sesquiterpene composed of 15 carbon atoms,mainly extracted from Ligularia,and has anti-tumor,antibacterial,anti-inflammatory and other biological activities.The basic structure types of irimofen alkane sesquiterpenes mainly include a lactone ring,dimer,furan ring,carbon reduction type and C19.In this paper,the structures and potential cytotoxicity of irimofenane sesqui-terpenes were reviewed,and the effects of specific known chemical structures on the anti-tumor activity were described,in order to provide reference for the study of their anti-tumor clinical therapeutic effects.
small molecule compoundseremophilane sesquiterpenesantitumor drugcytotoxicitystructure-activity relationship
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