药物减轻心肌缺血再灌注损伤机制研究的进展
Research progress on the mechanism of drugs in attenuating myocardial ischemia-reperfusion injury
邢阳 1冷玉芳 2赵潇 3李东阳 4兰金辉 1刘振 1李东斌 1王玉 1常利娅 1赵紫岑1
作者信息
- 1. 兰州大学 第一临床医学院,甘肃 兰州 730000
- 2. 兰州大学 第一临床医学院,甘肃 兰州 730000;兰州大学第一医院 麻醉手术科,甘肃 兰州 730000
- 3. 西安交通大学第二附属医院 消化内科,陕西 西安 710004
- 4. 吉林大学 白求恩第三临床医学院,吉林 长春 130000
- 折叠
摘要
心肌缺血再灌注损伤常见于心肌梗塞、心肌缺血等,其发病率、死亡率高,且缺乏防治措施.积极探究防治心肌缺血再灌注损伤是临床研究的热点,近5年有关药物减轻心肌缺血再灌注损伤及其机制的研究较多,也取得了一些进展.本文着重介绍近5年关于药物通过抑制铁死亡、细胞凋亡、坏死性凋亡、细胞焦亡、氧化应激、钙超载、自噬调控、内质网应激、能量代谢等机制减轻心肌缺血再灌注损伤的实验研究和临床观察,及利用纳米技术、冠状动脉内给药技术等防治心肌缺血再灌注损伤的新成果,为心肌缺血再灌注损伤防治和研究提供理论依据.
Abstract
Myocardial ischemia-reperfusion injury is common in myocardial infarction and myocardial ischemia,having a high incidence,high mortality and insufficient prevention and treatment measures.Actively exploring the prevention and treatment of myocardial ischemia-reperfusion injury has been a focus of clinical research.In the past five years,new progress has been made in the study of drugs that can reduce myocardial ischemia-reperfusion injury and the mechanisms.This article focused on the experimental research and clini-cal observation of drugs in the prevention and treatment of myocardial ischemia-reperfusion injury by in-hibiting ferroptosis,apoptosis,necroptosis,pyrosis,oxidative stress and calcium overload and regulating autophagy,endoplasmic reticulum stress and energy metabolism,and also the latest achievements in the pre-vention and treatment of myocardial ischemia-reperfusion injury by nanotechnology and intracoronary drug administration in the past five years,so as to provide a theoretical basis for the prevention and treatment of myocardial ischemia-reperfusion injury.
关键词
药物/心肌缺血再灌注/器官保护/细胞凋亡/自噬/氧化应激Key words
medicine/myocardial ischemia-reperfusion/organ protection/apoptosis/autophagy/oxidative stress引用本文复制引用
基金项目
国家自然科学基金(82260381)
兰州大学医学教育创新发展项目(lzuyxcx-2022-108)
出版年
2024
国家科技期刊平台
NSTL
万方数据