Immunotherapy,especially immune checkpoint inhibition,has become a crucial method in cancer treatment.However,only a minority of patients across most cancer types respond to immune checkpoint blockade.As our understanding of cancer immunotherapy deepens,the role of DNA damage and repair mecha-nisms in tumor immune evasion becomes increasingly significant.Studies have shown that genomic instability and defects in the DNA damage response,particularly in the context of radiation and chemotherapy,can enhance the efficacy of immune checkpoint blockade.Although current research has made positive strides,the precise regulation of DNA damage response and the optimization of combination therapy strategies to improve efficacy and reduce side effects remain key areas for future research.This article discussed in detail the immune modulation mechanisms of traditional genotoxic therapies such as radiotherapy and chemotherapy combined with immune checkpoint blockade,and explored the potentials for a stimulator of interferon gene agonists and DNA damage response inhibitors in combination therapy.Additionally,a new strategy was proposed based on a combined application of DNA damage response-targeted inhibition and immunotherapy,emphasizing the importance of integrating traditional treatments with novel immunomodulatory strategies and developing biomarkers.
关键词
DNA损伤应答/免疫检查点阻断/肿瘤免疫治疗/联合治疗/放射治疗/化学治疗/干扰素基因刺激因子
Key words
DNA damage response/immune checkpoint blockade/tumor immunotherapy/combination thera-py/radiotherapy/chemotherapy/stimulator of interferon gene
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