摘要
目的 探讨不同人群乙型肝炎(乙肝)预防策略之间的关联,为乙肝预防的决策制定和实践提供科学依据.方法 检索国内外乙肝指南和专家共识,提取乙肝预防推荐意见并抽取实体、关系和属性数据,利用Python的py2neo库调用数据,将其导入Neo4j图数据库中构建可视化知识图谱.结果 检索8个数据库和12个官方网站,共获得中文指南6部、专家共识2部,英文指南16部、专家共识2部,提取了260条预防相关推荐意见.根据推荐意见抽取得到适用人群、特殊人群、检测类操作、干预类操作、药物大类、具体药物名称、时机和推荐程度共8种实体,以及操作选择、最佳操作时间、用药选择、用药时间、进行和包含共6种关系,最终构建了筛查、疫苗接种、母婴阻断、管理策略和暴露后预防共5个知识图谱,为不同人群提供相应的乙肝预防策略.结论 乙肝预防策略知识图谱的构建有助于医疗工作者和公众更好地了解乙肝预防措施,为决策者制定更具针对性和有效性的乙肝防控策略提供科学依据,促进乙肝防控工作的全面展开和持续发展.
Abstract
Objective To explore the association between hepatitis B prevention strategies in different popula-tions and to provide a scientific basis for decision-making and practice in this field.Method Through a retriev-al of Chinese and international hepatitis B guidelines and expert consensus,recommendations for hepatitis B prevention were extracted along with the entity,relationship and attribute data.Subsequently,via the py2neo library in Python the data was imported into the Neo4j graph database to build visual knowledge graphs.Results A total of 8 databases and 12 official websites were searched,resulting in an acquisition of 6 Chinese guidelines,2 Chinese expert consensuses,16 English guidelines and 2 English expert consensuses,from which 260 prevention-related recommendations were extracted.Based on them,8 entities including popula-tion,special populations,virus-testing operations,medical interventions,drug classes,specific drug names,timing and level of recommendation were extracted,along with 6 types of relationships such as operation selection,optimal timing of operations,medication selection,timing of medication,implement,and inclusion.Ultimately,knowledge graphs for screening,vaccination,mother-to-child transmission prevention,manage-ment strategies,and post-exposure prevention were constructed to provide corresponding hepatitis B preven-tion strategies for different population groups.Conclusion The construction of the hepatitis B prevention strategy knowledge graphs facilitates healthcare workers and the public in better understanding hepatitis B prevention measures.It also provides a scientific basis for decision-makers to formulate more targeted and effective hepatitis B prevention and control strategies,thereby promoting comprehensive and sustainable development in hepatitis B prevention and control efforts.
基金项目
中国中医科学院科技创新工程资助项目(CI2021A05502)
维普
万方数据