Progress in research of microRNA regulating nuclear factor κB signaling pathway in the pathogenesis and treatment of chronic obstructive pulmonary disease
MicroRNA is a type of endogenous single-chain non-coding RNA molecule that is specifically combined with the target mRNA-specific level after target genetic transcription having been regulated.The nuclear factor κB is a nuclear transcription factor that regulates the apoptosis and inflammation,which is closely related to the development of chronic obstructive pulmonary disease.Recent studies have found that microRNA can participate in the occurrence and development of chronic obstructive pulmonary disease by regulating the expression of the downstream target gene nuclear factor κ B.This article mainly reviewed the microRNAs and nuclear factor κB signaling pathway involved in the pathogenesis of chronic obstructive pulmonary disease,so as to provide a theoretical basis for exploring new diagnostic biomarkers and potential therapeutic targets for chronic obstructive pulmonary disease.
万方数据
维普
