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肺部微生物对心血管疾病的影响

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肺部微生物对人类健康和疾病起重要作用,可通过氧化应激、免疫炎症和补体形成等多种机制对心血管疾病的发生发展产生促进作用,导致心血管疾病恶化,甚至威胁生命。本文综述肺部微生物的起源、进展、现状、组成和主要生理功能及其对心血管疾病的影响,为调控肺部微生物的抗心血管疾病策略提供新的理论依据,围绕肺部微生物的作用机理为心血管疾病的防治提供新的治疗靶点、拓展新思路。
Impact of pulmonary microbiome on cardiovascular disease
Lung microbes play an important role in human health and disease,pulmonary microorganisms can promote the occurrence and development of cardiovascular diseases through various mechanisms such as oxidative stress,immune inflammation and complement formation,leading to a deterioration of cardiovascu-lar diseases and even threatening life.This paper reviewed the origin,progress and status quo of pulmonary microorganisms,the composition and main physiological functions of pulmonary microorganisms,and the impact of pulmonary microbial abnormalities on cardiovascular diseases,so as to provide a new theoretical basis for anti-cardiovascular disease strategies based on a regulation of pulmonary microorganisms.It could also provide new therapeutic targets and develop new ideas for the prevention and treatment of cardiovascular diseases by centering on the mechanism of pulmonary microorganisms.

pulmonary microbiomecardiovascular diseasestreptococcus pneumoniaeChlamydia pneumoni-aesevere acute respiratory syndrome coronavirus 2mycoplasma pneumoniae

张梦洁、陈薇、卢恒、王小花、王爱平、冯荣

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南华大学 衡阳医学院,湖南 衡阳 421001

长沙市第一医院 心血管内一科,湖南 长沙 410005

肺部微生物 心血管疾病 肺炎链球菌 肺炎衣原体 严重急性呼吸系统综合征冠状病毒2 肺炎支原体

国家自然科学基金资助项目

81600040

2024

兰州大学学报(医学版)
兰州大学

兰州大学学报(医学版)

CSTPCD
影响因子:0.641
ISSN:1000-2812
年,卷(期):2024.50(7)