A multi-omics-based exploration of the expression profile and clinicopathological association of STIP1 in hepatocellular carcinoma
Objective To investigate the functional characteristics and clinical significance of stress induced phosphoprotein 1(STIP1)in hepatocellular carcinoma(HCC)based on multi-omics.Methods Based on the mRNA expression data of HCC from the public database,the expression of STIP1 in HCC tissues was ana-lyzed multidimensionally.The correlation between STIP1 and the abundance of tumor immune cell infiltra-tion,immune checkpoints and chemokines was analyzed,and a prognostic nomogram model was constructed based on the expression level of STIP1 and linicopathological characteristics.Results STIP1 was significantly up-regulated in hepatocellular carcinoma and meanningfully correlated with the histologic grade,pathological stage,T stage,N stage,M stage,body mass indes,α-fotoprotein expression level,as well as the degree of liver fibrosis.The high expression of STIP1 was significantly correlated with a poor survival prognosis of patients,and STIP1 showed good diagnostic efficacy for hepatocellular carcinoma.The expression level of STIP1 was significantly correlated with the abundance of CD4+T cells,T cell regulatory cells,monocytes,and infil-trated myeloid dendritic cells as well as with some immune checkpoints in hepatocellular carcinoma.STIP1 also correlated with sensitivity to chemotherapy and targeted therapies in some hepatocellular carcinomas.Conclusion STIP1 may be a prognostic marker and a potential predictive target in hepatocellular carcinoma,and there is a correlation between STIP1 and drug sensitivity in hepatocellular carcinoma.
国家科技期刊平台
NSTL
万方数据
