Efficacy and safety of ciprofol versus propofol in general anes-thesia induction for abdominal surgery
Objective To investigate the efficacy and safety of ciprofol in general anesthesia induction for ab-dominal surgery.Methods Patients undergoing abdominal surgery were randomly separated into two groups:the Propofol and the Ciprofol group,with 54 in each.The induction success rate,time to loss of eyelash reflex after drug administration,time for the anesthesia index to 60,and time to tracheal intubation were recorded.Fluctuation of blood pressure and heart rate during induction,use of rescue drugs and vasoactive drugs,and the occurrence of adverse events such as nausea and somnolence within 30 minutes after extubation,etc.were recorded.Results The induction success rate was 96.3%in the Propofol group and 100%in the Ciprofol one,respectively,with no statistical significance(P>0.05),and the induction dose in the former significantly lower than that in the latter(P<0.05).The time for the anesthesia index to 60 and tracheal intubation in the Ciprofol group was significantly shorter compared to the Propofol group(P<0.05).No significant difference was observed in the time to loss of eyelash reflex between the two.Mean artery pressure values before and after endotracheal intubation were lower in both than in basic mean arterial pressure,and the decrease in the Ciprofol group was lower than that in the Propofol group(P<0.05).The changes in heart rate were irreg-ular in both groups,and blood oxygen saturation increased after oxygen inhalation and remained stable in both.The Ciprofol group had a notably lower incidence of injection pain and adverse reactions compared to the Propofol group(P<0.05).Conclusion The induction effect of ciprofol in abdominal surgery is slightly better than that of propofol.Ciprofol has the advantages of minimal impact on the circulatory system and a lower incidence of adverse reactions such as injection pain.
ciprofolpropofolgeneral anesthesiamajor abdominal surgery
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