远隔缺血适应改善急性脑梗死患者神经功能的临床研究
Clinical research into remote ischemic conditioning on improving neurological function in patients with acute cerebral infarction
马临庆 1张立梅 1任丽艳 1孙璐 1崔俊一 1周丽华1
作者信息
- 1. 苏州高新区人民医院 神经内科,江苏 苏州 215129
- 折叠
摘要
目的 探讨远隔缺血适应对急性脑梗死患者神经功能、行动能力的影响以及临床疗效和治疗安全性.方法 选取2022年1月—2023年12月苏州高新区人民医院神经内科经磁共振确诊的颈内动脉系统急性脑梗死,美国国立卫生研究院卒中量表评分6～16分的患者178例作为研究对象并随机分为试验组(n=92)和对照组(n=86).试验组和对照组均接受标准治疗,试验组同时进行了远隔缺血适应疗法,治疗6个月后随访,评估两组患者的疗效及治疗相关的不良事件.结果 治疗6个月后,试验组改良的Rankin量表评分为0～1分的患者比例高于对照组(70.65%vs 54.65%,P<0.05).试验组上肢Fugl-Meyer评分为(48.26±5.20)分,高于对照组的(37.50±3.10)分(P<0.05);试验组下肢Fugl-Meyer评分为(33.42±3.50)分,高于对照组的(28.60±2.50)分(P<0.05).两组患者的美国国立卫生研究院卒中量表评分比入院时均有降低,试验组下降为(5.96±1.99)分,对照组下降为(9.04±2.94)分,两组美国国立卫生研究院卒中量表评分差异有统计学意义(P<0.05).结论 在标准治疗基础上加用远隔缺血适应疗法对急性脑梗死患者的康复有明显益处,能有效提升治疗效果,改善患者的临床症状,降低残疾率.
Abstract
Objective To investigate the effects of remote ischemic conditioning(RIC)treatment on neurologi-cal function,mobility,clinical efficacy and safety in patients with acute cerebral infarction.Methods A total of 178 patients,who were diagnosed with acute cerebral infarction in the internal carotid artery system(NI-HSS score of 6-16)via magnetic resonance imaging at the neurology department of The People's Hospital of Suzhou New District between January 2022 and December 2023 were selected as the study subjects.They were assigned to an experimental group(n=92)and a control one(n=86).The former received additional RIC therapy accompanied by standard treatment,and the latter only standard treatment.After six months of treat-ment,the efficacy and treatment-related adverse events of the two groups were carefully evaluated and com-pared.Statistical analysis was conducted on the patient's neurological function,mobility,clinical efficacy score,and treatment safety before and after the treatment.Results After six months of follow-up,70.65%of patients in the treatment group had an mRS score of 0-1,significantly higher than the control group(54.65%,P<0.05).The Fugl-Meyer score of upper limbs in the treatment group was(48.26±5.20),which was signifi-cantly improved compared with(37.50±3.10)in the control(P<0.05).At the same time,the lower limbs Fugl-Meyer score of(33.42±3.50)in the treatment group was also significantly higher than(28.60±2.50)in the control(P<0.05).The NIHSS scores of both were lower than that at admission,and the score in the experimental group decreased to(5.96±1.99),which was lower than the control's(9.04±2.94)(P<0.05).Conclusions The addition of RIC therapy on the basis of standard treatment has significant benefits for the rehabilitation of patients with acute cerebral infarction.It can effectively enhance the treatment effect,im-prove the patient's symptoms,and reduce disability rates.
关键词
急性脑梗死/远隔缺血适应/美国国立卫生研究院卒中量表/改良Rankin评分/有效性/安全性Key words
acute cerebral infarction/remote ischemic conditioning/national institutes of health stroke scale/modified rankin scale/validity/security引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据