基因多态性在全身麻醉药物中的研究进展
Progress in research of genetic polymorphism in general anesthesia drugs
于敏 1李亚龙 2胡晓霞 3马玉龙 2刘欣跃2
作者信息
- 1. 兰州大学第二医院 麻醉科,甘肃 兰州 730030
- 2. 兰州大学第二医院 检验医学中心,甘肃 兰州 730030
- 3. 兰州大学第二医院 特需内科,甘肃 兰州 730030
- 折叠
摘要
药物在体内的代谢过程涉及多种蛋白质,如代谢酶、转运蛋白质和受体等,这些蛋白质的合成受到基因的控制.药物基因组学是研究基因和基因功能变化如何影响药代动力学和药效学的学科,基因多态性通过影响药物代谢酶、受体蛋白编码基因的多态性改变药物代谢速度及药理效应.麻醉药物作为调节神经系统功能的药物,在个体差异方面存在明显不同,这可能是个体临床特征和遗传因素共同造成的.本文对近年来基因多态性在全身麻醉药物中的研究进行回顾和总结,以期有助于临床麻醉精准用药的实施,提高药物疗效,减轻药物副作用.
Abstract
The metabolic process of drugs in the body involves various proteins,such as metabolic enzymes,transport proteins and receptors,and the synthesis of these proteins is controlled by genes.Pharmacogenomics is a discipline studying how changes in gene function affect pharmacokinetics and pharmacodynamics.Gene polymorphism affects the metabolism rate and pharmacological effects by affecting the polymorphism of genes's encoding drug metabolism enzymes and receptor proteins.Anesthetic drugs,as ones regulating the function of the nervous system,show significant differences in individuals,which may be due to a combi-nation of individual clinical characteristics and genetic factors.This review provided a summary of recent research on genetic polymorphism in general anesthetic drugs,aiming at contributing to the implementation of precision anesthesia in clinical practice,enhancing drug efficacy and reducing adverse drug reactions.
关键词
麻醉药/基因多态性/静脉麻醉药/吸入麻醉药/阿片类药物/肌松药Key words
anesthetics/genetic polymorphism/intravenous anesthetics/inhalation anesthetics/opioid drugs/muscle relaxants引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据