Research progress in microglia regulation of depression-related central nervous system disorders
Depression is associated with a range of intricate alterations in the central nervous system,such as microglia activation,neuroinflammation,neurotransmitter imbalances,and modifications in neuroplasticity.Although microglia play a crucial role in these changes,its relationship with these processes remains unclear.The objective of this review was to made a comprehensive overview of the roles played by microglia in regu-lating the central nervous system druing both normal physiological states and depressive conditions.Specifi-cally,we focused on their activation in depression and examined how they interact with neuroinflammation,dysregulation of the hypothalamic-pituitary-adrenal axis,imbalances in neurotransmitters,and alterations in neuroplasticity.These together would further our systematic understanding of the biological mechanisms under-lying depression,and provide a theoretical basis for identifying novel therapeutic targets for this disorder.
国家科技期刊平台
NSTL
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