不同病理特征乳腺癌患者BI-RADS分类、剪切波速度及糖类抗原153的差异分析
Differences of BI-RADS classification,shear wave velocity and carbohydrate antigen 153 in breast cancer patients with different pathological characteristics
刘小蓝 1麦湘湘 1孙章秀 1张亚庆1
作者信息
- 1. 570311 海口市,海南医学院第二附属医院超声医学科
- 折叠
摘要
目的 分析不同病理特征乳腺癌患者BI-RADS分类、剪切波速度(SWV)和糖类抗原153(CA153)的差异,为乳腺癌临床诊断和病情评估提供参考.方法 选取我院经手术病理证实的乳腺癌患者106例,术前均行常规超声检查并进行BI-RADS分类,声触诊组织量化技术测量病灶SWV,采用酶联免疫吸附法检测CA153,分析不同病理类型、组织学分级、分子分型及淋巴结转移状态乳腺癌患者上述检测结果的差异.结果 不同病理类型乳腺癌患者中,浸润性小叶癌SWV高于导管原位癌、浸润性导管癌及其他类型,浸润性导管癌及其他类型SWV高于导管原位癌,差异均有统计学意义(均P<0.05);不同病理类型乳腺癌患者BI-RADS分类和CA153比较差异均无统计学意义.不同组织学分级乳腺癌患者中,1、2、3级SWV依次增大,且两两比较差异均有统计学意义(均P<0.05);不同组织学分级乳腺癌患者BI-RADS分类和CA153比较差异均无统计学意义.不同分子分型乳腺癌患者中,Luminal B(HER2+)型SWV高于Luminal A型、Luminal B(HER2-)型及三阴性,Luminal A型SWV低于其余分子分型,差异均有统计学意义(均P<0.05);不同分子分型乳腺癌患者BI-RADS分类和CA153比较差异均无统计学意义.不同淋巴结转移状态乳腺癌患者中,淋巴结转移者BI-RADS分类、SWV及CA153与淋巴结未转移者比较,差异均有统计学意义(均P<0.05).结论 不同病理类型、组织学分级、分子分型及淋巴结转移状态乳腺癌患者SWV均存在明显差异,不同淋巴结转移状态乳腺癌患者BI-RADS分类、CA153均存在明显差异,可为乳腺癌临床诊断和病情评估提供参考依据.
Abstract
Objective To analyze the differences of BI-RADS classification,shear wave velocity(SWE)and carbohydrate antigen 153(CA153)in breast cancer patients with different pathological characteristics,and to provide reference for clinical diagnosis and disease evaluation of breast cancer.Methods Totally 106 breast cancer patients confirmed by surgical pathology were selected in our hospital.Before surgery,all the patients received conventional ultrasonography for BI-RADS classification,and underwent virtual touch tissue imaging quantification technology to detect the SWV in lesions.CA153 was detected by immunosorbent assay,and the differences of the above detection results in breast cancer patients with different pathological types,histological grades,molecular types and lymph node metastasis status were analyzed.Results Among breast cancer patients with different pathological types,the SWV of patients with invasive lobular carcinoma was higher than that of patients with ductal carcinoma in situ,invasive ductal carcinoma and other disease,and the SWV of patients with ductal carcinoma in situ was higher than that of patients with invasive ductal carcinoma and other disease,the differences were statistically significant(all P<0.05).However,there were no statistical differences in the BI-RADS classification and CA153.Among breast cancer patients with different histological grades,the SWV of patients with histological grade 3 was higher than that of grade 1 and 2,as well as higher in patients with grade 2 than that of grade 1(all P<0.05),but no statistical differences in BI-RADS classification and CA153.Among breast cancer patients with different molecular types,the SWV of patients with Luminal B(HER 2+)type was higher than that of Luminal A type,Luminal B(HER 2-)type and triple-negative,the SWV of Luminal A type was lower than that of other types,the differences were statistically significant(all P<0.05),while the differences in BI-RADS classification and CA153 were not statistically significant.Among breast cancer patients with different lymph node metastasis status,there were significant difference in BI-RADS classification,SWV and CA153 between patients without lymph node metastasis and patients with lymph node metastasis,the differences were statistically significant(all P<0.05).Conclusion SWV is significantly different among breast cancer patients with different pathological types,histological grades,pathological molecular types and lymph node metastasis status,while BI-RADS classification and CA153 are obviously different among breast cancer patients with different lymph node metastasis status,which can provide reference information for clinical diagnosis and disease evaluation of breast cancer.
关键词
超声检查/BI-RADS分类/剪切波速度/糖类抗原153/乳腺癌/病理特征Key words
Ultrasonography/BI-RADS classification/Shear wave velocity/Carbohydrate antigen 153/Breast cancer/Pathological characteristics引用本文复制引用
基金项目
海南省卫生健康行业科研项目(21A200202)
出版年
2024
NETL
NSTL
万方数据