Objective To establish reference values for normal fetal maxillary and mandibular parameters in first trimester by multi-sectional ultrasound measurements.Methods A total of 322 normal fetuses underwent first-trimester ultrasound examination in our hospital were selected.Ultrasound measurements were performed for fetal crown-rump length(CRL),length of the palatal line,maxillary transverse diameter,primary palate width and transverse diameter,anteroposterior diameter,length and gap of the mandible.The correlation between each parameter of fetal maxilla and mandible with gestational age,CRL were analyzed,and the linear regression equations were fitted.Results In 322 cases,the length of the palatal line,maxillary transverse diameter,primary palatal width,transverse diameter of the mandible,anteroposterior diameter of the length of mandible,and gap of mandible were 7.3(6.5,8.0)mm,8.2(7.3,9.3)mm,6.3(4.8,7.5)mm,8.4(7.2,9.9)mm,4.5(3.4,5.7)mm,8.4(7.4,9.6)mm and 2.1(1.7,2.7)mm,respectively.Among maxillary parameters,maxillary transverse diameter had the highest correlation coefficient with gestational age and CRL(r=0.658,0.664,both P<0.001).The linear regression equations of maxillary transverse diameter and gestational age,CRL were as follow:maxillary transverse diameter(mm)=1.67×gestational age-12.57,maxillary transverse diameter(mm)=0.13×CRL+0.80.Among mandibular parameters,the transverse diameter of mandible had the highest correlation coefficient with gestational age and CRL(r=0.704,0.698,both P<0.001).The linear regression equations of mandibular transverse diameter and gestational age,CRL were as follow:mandibular transverse diameter(mm)=2.39×gestational age-21.20,mandibular transverse diameter(mm)=0.18×CRL-2.06.Conclusion This study establishes reference values for maxillary and mandible ultrasound of normal fetuses in first trimester,and it can provide a certain reference value for fetal maxillofacial assessment and screening of developmental abnormalities of fetuses in first trimester.
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