Objective To evaluate the fetal heart morphology and systolic function in pregnant women with acquired thrombophilia by fetal heart quantification(Fetal HQ),and to explore its clinical application value.Methods A total of 24 pregnant women diagnosed with acquired thrombophilia(case group)and 40 healthy pregnant women during the same period(control group)in our hospital were selected,and the related parameters of placental function were detected by spectral Doppler,including the ratio of peak systolic velocity to peak diastolic velocity of umbilical artery(UA S/D),umbilical artery pulsatility index(UA PI),middle cerebral artery pulsatility index(MCA PI),ductus venosus pulsatility index(DV PI),cerebral placental ratio.Fetal HQ was used to measure fetal heart morphological parameters[global spherical index(GSI)]and functional parameters[left and right ventricular global longitudinal strain(LVGLS,RVGLS),area change fraction(LVFAC,RVFAC),free wall strain(LVFWS,RVFWS),left ventricular septal wall strain(LVSWS),left ventricular ejection fraction(LVEF)],and the differences of the above parameters between the two groups were compared.The correlation between placental functional parameters and Fetal HQ parameters were analyzed.Results The fetal UA S/D in the case group was higher than that in the control group,and the difference was statistically significant(P=0.007).There were no significant difference in fetal UA PI,MCA PI,DV PI and cerebral placental ratio between the two groups.The fetal RVGLS,RVFAC and RVFWS in the case group were significantly lower than those in the control group,and the differences were statistically significant(all P<0.05).There were no significant difference in fetal GSI,LVEF,LVGLS,LVFAC,LVFWS and LVSWS between the two groups.Correlation analysis showed that fetal UA S/D in the case group was negatively correlated with RVGLS,RVFAC and RVFWS(r=-0.534,-0.624,-0.570,all P<0.05).Conclusion Fetal HQ could accurately assess the fetal heart morphology and systolic function in pregnant women with acquired thrombophilia,which has good clinical application value.
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