Clinical value of ultrasound measurement of prefrontal space ratio combined with non-invasive prenatal testing in screening fetal chromosomal abnormalities in early pregnancy
Objective To measure the prefrontal space ratio(PFSR)by ultrasound,and to explore the clinical application value of the method combined with non-invasive prenatal testing(NIPT)in screening fetal chromosomal abnormalities in early pregnancy.Methods A total of 80 high-risk pregnant women who received amniocentesis chromosome karyotype detection in our hospital were selected.All of them underwent prenatal ultrasound examination and NIPT.Amniocentesis chromosome karyotype detection results were taken as the gold standard,the diagnostic efficacy of ultrasound measurement of PFSR,NIPT and their combined application in screening fetal chromosomal abnormalities in early pregnancy were compared.Results Among the 80 high-risk pregnant women,11 cases were screened for fetal chromosomal abnormalities by amniocentesis,including 6 cases of trisomy 21 syndrome,2 cases of trisomy 18 syndrome,2 cases of trisomy 13 syndrome,and 1 case of Turner syndrome.The sensitivity,specificity and accuracy of ultrasound measurement of PFSR for screening fetal chromosomal abnormalities in early pregnancy were 63.64%,86.96%and 83.75%,respectively.The sensitivity,specificity and accuracy of NIPT were 72.73%,88.41%and 86.25%,respectively.The sensitivity,specificity and accuracy of the combination of the two methods were 90.91%,98.55%and 97.50%,respectively,which were higher than those of the single method,and the differences were statistically significant(all P<0.05).Conclusion Ultrasound measurement of PFSR combined with NIPT could improve the diagnostic efficacy for screening fetal chromosomal abnormalities in early pregnancy,and has good clinical application value.
Ultrasonography,prenatalPrefrontal space ratioNon-invasive prenatal testingChromosomal abnormalityFetus
NETL
NSTL
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