Clinical value of contrast-enhanced ultrasound quantitative parameters combined with serum indexes in the evaluation of inflammatory activity in Crohn's disease
Objective To explore the clinical value of contrast-enhanced ultrasound quantitative parameters combined with serum indexes in the evaluation of inflammatory activity in Crohn's disease(CD).Method A total of 95 patients with CD who visited our hospital were selected and divided into inflammatory active phase group(67 cases)and non inflammatory active phase group(28 cases)according to whether they were in the inflammatory active phase.The differences of contrast-enhanced ultrasound quantitative parameters[time to peak(TTP),rise time(RT),peak intensity(PI)]and serum indexes(miR-223,IL-6)were compared between the two groups.Receiver operating characteristic(ROC)curve was drawn to analyze the value of contrast-enhanced ultrasound quantitative parameters,serum indexes applied alone and their combination in evaluating the inflammatory activity in CD.Results Compared with the non inflammatory active phase group,the inflammatory active group showed a decreasing in TTP and RT,and an increasing in PI and serum miR-223,IL-6,with statistical significance(all P<0.05).ROC curve analysis showed that the area under the curve of TTP,RT,PI,serum miR-223,IL-6,and their combined application for evaluating inflammation activity in CD were 0.735,0.703,0.796,0.858,0.805,and 0.962.The sensitivity and specificity were 100.0%,97.0%,80.6%,73.1%,50.7%,97.0%and 50.0%,46.4%,67.9%,89.3%,100%,96.4%,respectively.Conclusion The combination of contrast-enhanced ultrasound quantitative parameters and serum indexes has high evaluation value for CD inflammation activity.
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