Objective To analyze the correlation between the rectus abdominis muscle thickness measured by ultrasound and the cachexia stage in patients with malignant tumors.Methods sixty-eight patients with malignant tumors who reexamined in our hospital were selected as tumor group.According to the cachexia score table,the patients were divided into no cachexia group(10 cases),pre-cachexia group(16 cases),cachexia group(32 cases)and cachexia refractory group(10 cases),and 41 healthy volunteers were selected as the healthy group.Baseline data and laboratory indicators(white blood cell count,hemoglobin and albumin)were recorded.The rectus abdominis muscle thickness and abdominal median subcutaneous fat thickness were measured by ultrasound,and the ratio of rectus abdominis muscle thickness to body mass index(BMI)was calculated.The differences of above parameters between the tumor group and the healthy group,different cachexia stage in tumor group were compared.The correlation between rectus abdominis muscle thickness and the cachexia stage was analyzed.Results There were significant differences in body weight,white blood cell count,hemoglobin,albumin,rectus abdominis muscle thickness and the ratio of rectus abdominis muscle thickness to BMI between the tumor group and the healthy group(all P<0.05).There was no difference in the abdominal median subcutaneous fat thickness.There were differences in the rectus abdominis muscle thickness between cachexia refractory group and pre-cachexia group,cachexia refractory group and no cachexia group,cachexia group and no cachexia group(all P<0.05).There were significant differences in white blood cell count,hemoglobin and albumin at different cachexia stage in tumor group(all P<0.05).Correlation analysis showed that the rectus abdominis muscle thickness was negatively correlated with the cachexia stage(rs=-0.521,P<0.001),and moderately positively correlated with body mass(rs=0.435,P<0.001).Conclusion The rectus abdominis muscle thickness measured by ultrasound in patients with malignant tumors decreases with the severity of cachexia increases.Ultrasound can accurately assess muscle wasting and may become a new method for evaluating the severity of cachexia.
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