Objective To explore the clinical value of color Doppler ultrasound combined with serological detection in the diagnosis of late-onset fetal growth restriction(FGR).Methods A total of 46 late pregnant women with confirmed FGR(FGR group)and 46 late pregnant women with normal fetal development(control group)were selected from our hospital.Color Doppler ultrasound was used to measure the ratio of systolic and diastolic(S/D)of the umbilical artery,the pulsatility index of the middle cerebral artery and umbilical artery,and the cerebroplacental ratio(CPR)was calculated.Clinical data were collected,and serum placental growth factor(PLGF),soluble vascular endothelial factor receptor-1(sFlt-1)were detected.The differences of above parameters between the two groups were compared.The independent influencing factors of late-onset FGR were analyzed by multivariate Logistic regression analysis.The diagnostic efficiency of ultrasound and serum parameters used alone and combined for predicting late-onset FGR was analyzed by receiver operating characteristic(ROC)curve.Results The proportion of gestational hypertension,umbilical artery S/D and serum sFlt-1 in the FGR group were higher than those in the control group,while CPR and serum PLGF were lower than those in the control group(all P<0.05).Multivariate Logistic regression analysis showed that umbilical artery S/D,CPR,serum PLGF and sFlt-1 were independent influencing factors for late-onset FGR(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of umbilical artery S/D,CPR,serum PLGF and sFlt-1 for predicting late-onset FGR were 0.783,0.835,0.874 and 0.841,respectively.AUC for umbilical artery S/D ratio combined with serum PLGF and sFlt-1,CPR combined with serum PLGF and sFlt-1 were 0.971 and 0.981,respectively,while the AUC for the combination of all four parameters was 0.990,which was higher than each single parameter(all P<0.05).Conclusion Color Doppler ultrasound combined with serological detection has high diagnostic efficiency for late-onset FGR,with the combined application providing higher diagnostic value.
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