Objective To explore the application value of ultrasound in quantitative evaluation of renal hemodynamic parameters changes in rabbits with acute cold exposure.Methods Eighteen healthy adult male New Zealand large white rabbits were selected and divided into 4 time periods according to time sequence:T1 time period(room temperature),T2 time period(acute cold exposure),T3 time period(1st rewarming)and T4 time period(2nd rewarming to basal body temperature).The rabbits were divided into rewarming success group and rewarming failure group according to the survival or death outcome of rabbits after acute cold exposure.Differences in body temperature(Tc),serum creatinine(CREA),urea nitrogen(UREA),and ultrasound hemodynamic parameters of right renal arery[renal segmental artery peak systolic flow velocity(PSV),and renal artery trunk PSV,time averaged mean velocity(TAMEAN),renal artery trunk diameter(d),volume of blood flow(VolFlow)]were compared between the two groups in each time period.Results There were 13 rabbits in rewarming success group and 5 rabbits in rewarming failure group,of which 1 rabbit failed in T3 time period and 4 rabbits failed in T4 time period.①Comparison of Tc beween two groups:compared with T1 time period,Tc decreased in both groups in T2 time period(both P<0.05),Tc in T3 time period was higher than that in T2 time period,but not as high as that in T1 time period,and the differences were statistically significant compared with T1 and T2 time period(both P<0.05).Tc of rewarming success group in T4 time period was higher than that in T2 and T3 time period(both P<0.05),and reached to the level of T1 time period,with no statistical significance compared with T1 time period.The differences between the two groups were not statistically significant in Tc from T1 to T3 time periods.②Comparison of renal function beween two groups:compared with T1 time period,the CREA increased in T2 time period in both groups(both P<0.05).The difference in UREA in each time peroid was not statistically significant between the two groups.③Comparison of ultrasound hemodynamic parameters of right renal arery beween two groups:compared with T1 time period,all ultrasound hemodynamic parameters of right renal arery in rewarming success group decreased in T2 time period(all P<0.001),renal segmental artery PSV,renal artery trunk PSV and TAMEAN in T3 time period were higher than those in T2 time period(all P<0.05),and renal artery trunk d and VolFlow in T3 time period were higher than those in T2 time period,but not as high as that in T1 time period(both P<0.05).All ultrasound hemodynamic parameters of right renal arery in T4 time period were higher than those in T2 time period,and renal artery trunk VolFlow was higher than that in T3 time period(all P<0.05).The pairwise comparison of other parameters in each period showed no statistical significance.In rewarming failure group,compared with T1 time period,the renal segmental artery PSV,and renal artery trunk PSV,TAMEAN,VolFlow decreased in T2 time period(all P<0.05),and there were no significant difference of all ultrasound hemodynamic parameters of right renal arery between T3 time period and T1,T2 time period.In rewarming failure group,renal artery trunk PSV,TAMEAN in T3 time period,renal artery trunk d and VolFlow in T2 and T3 time periods were lower than those in rewarming success group(all P<0.05).The differences were not statistically significant in renal segmental artery PSA from T1 to T3 time periods,renal artery trunk PSV and TAMEAN in T1 and T2 time periods,renal artery trunk d and VolFlow in T1 time period between the two groups.Conclusion Ultrasound have potential application value in quantitative evaluation of renal hemodynamic parameters changes in rabbits with acute cold exposure.
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