Objective To compare the diagnostic value of Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in hepatocellular carcinoma(HCC).Methods Forty-three patients with liver space occupying lesions were selected from our hospital(55 lesions),including 41 HCC and 14 benign lesions.The imaging features in both Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI were observed.The diagnostic accuracy,sensitivity and specificity of Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in the diagnosis of HCC were compared,respectively,and Kappa test was performed to analyse their consistency.Results There were statistically significant differences in the enhancement characteristics of Sonazoid contrast-enhanced ultrasound between HCC and benign lesions in the arterial phase,delayed phase and late vascular(Kupffer phase,all P<0.05).Among them,HCC mainly showed high enhancement in the arterial phase(75.61%),equal or low enhancement in the delayed phase,and mainly showed low enhancement in the Kupffer phase(85.37%).There were statistically significant differences in the enhancement characteristics of gadoxetic acid-enhanced MRI between HCC and benign lesions in the arterial and hepatobiliary phases(both P<0.05).Among them,high signal was mainly observed in the HCC arterial phase(65.85%),and low signal was mainly observed in the hepatobiliary phase(73.17%).The diagnostic accuracy,sensitivity and specificity of Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in diagnosing HCC were 87.27%,90.24%,78.57%and 90.91%,92.68%,85.71%,respectively,and there were no statistically significant difference between the two imaging techniques.The consistency between Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in the diagnosis of HCC was good(Kappa=0.908).Conclusion The diagnostic efficacy of Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in HCC is equivalent.
UltrasonographyContrast agentSonazoidGadoxetic acid-enhanced MRILiver space occupying lesionsHepatocellular carcinoma
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