Sonazoid超声造影与普美显增强MRI诊断肝细胞肝癌的对比研究
Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in the diagnosis of hepatocellular carcinoma:a comparative study
张雨 1汤群锋 2吴鸣宇 3杨树东 4周锋盛1
作者信息
- 1. 214023 江苏省无锡市,南京医科大学附属无锡人民医院南京医科大学无锡医学中心超声医学科
- 2. 214023 江苏省无锡市,南京医科大学附属无锡人民医院南京医科大学无锡医学中心医学影像科
- 3. 214023 江苏省无锡市,南京医科大学附属无锡人民医院南京医科大学无锡医学中心肝胆外科
- 4. 214023 江苏省无锡市,南京医科大学附属无锡人民医院南京医科大学无锡医学中心病理科
- 折叠
摘要
目的 对比Sonazoid超声造影与普美显增强MRI对肝细胞肝癌(HCC)的诊断价值.方法 选取我院肝脏占位性病变患者43例,共计55个病灶,其中HCC 41个,良性病灶14个.观察HCC与良性病灶的Sonazoid超声造影及普美显增强MRI图像特征,比较二者对HCC的诊断准确率、灵敏度、特异度;采用Kappa检验分析二者的一致性.结果 HCC与良性病灶在动脉期、延迟期及血管后期(Kupffer期)的超声造影增强特征比较差异均有统计学意义(均P<0.05),其中HCC动脉期以高增强为主(75.61%),延迟期均呈等或低增强,Kupffer期以低增强为主(85.37%).HCC与良性病灶在动脉期和肝胆期的增强MRI增强特征比较差异均有统计学意义(均P<0.05),其中HCC动脉期以高信号为主(65.85%),肝胆期以低信号为主(73.17%).Sonazoid超声造影和普美显增强MRI对HCC的诊断准确率、灵敏度、特异度分别为87.27%、90.24%、78.57%和90.91%、92.68%、85.71%,二者比较差异均无统计学意义.Sonazoid超声造影与普美显增强MRI诊断HCC的一致性好(Kappa=0.908).结论 Sonazoid超声造影对HCC的诊断效能与普美显增强MRI相当.
Abstract
Objective To compare the diagnostic value of Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in hepatocellular carcinoma(HCC).Methods Forty-three patients with liver space occupying lesions were selected from our hospital(55 lesions),including 41 HCC and 14 benign lesions.The imaging features in both Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI were observed.The diagnostic accuracy,sensitivity and specificity of Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in the diagnosis of HCC were compared,respectively,and Kappa test was performed to analyse their consistency.Results There were statistically significant differences in the enhancement characteristics of Sonazoid contrast-enhanced ultrasound between HCC and benign lesions in the arterial phase,delayed phase and late vascular(Kupffer phase,all P<0.05).Among them,HCC mainly showed high enhancement in the arterial phase(75.61%),equal or low enhancement in the delayed phase,and mainly showed low enhancement in the Kupffer phase(85.37%).There were statistically significant differences in the enhancement characteristics of gadoxetic acid-enhanced MRI between HCC and benign lesions in the arterial and hepatobiliary phases(both P<0.05).Among them,high signal was mainly observed in the HCC arterial phase(65.85%),and low signal was mainly observed in the hepatobiliary phase(73.17%).The diagnostic accuracy,sensitivity and specificity of Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in diagnosing HCC were 87.27%,90.24%,78.57%and 90.91%,92.68%,85.71%,respectively,and there were no statistically significant difference between the two imaging techniques.The consistency between Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in the diagnosis of HCC was good(Kappa=0.908).Conclusion The diagnostic efficacy of Sonazoid contrast-enhanced ultrasound and gadoxetic acid-enhanced MRI in HCC is equivalent.
关键词
超声检查/造影剂/Sonazoid/普美显增强MRI/肝脏占位性病变/肝细胞肝癌Key words
Ultrasonography/Contrast agent/Sonazoid/Gadoxetic acid-enhanced MRI/Liver space occupying lesions/Hepatocellular carcinoma引用本文复制引用
出版年
2024
NETL
NSTL
万方数据