Objective To explore the efficacy of high-intensity focused ultrasound(HIFU)ablation in the treatment of patients with recurrent adenomyosis(AM).Methods Ninety-two patients with recurrent AM who underwent HIFU ablation in our hospital were prospectively selected.Contrast-enhanced ultrasound was used to observe the ablation condition,and the average ablation rate immediately after HIFU ablation was calculated.Follow-ups were performed at 3,6,12,18 and 24 months post-ablation to assess recurrence,dysmenorrhea,uterine size and pregnancy status.Results The average ablation rate of 92 patiens with recurrent AM was(76.67±6.22)%immediately after HIFU ablation,and no ablation-related complications occurred.The dysmenorrhea relief rates at 3,6,12,18 and 24 months after ablation were 88.04%,75.00%,55.43%,42.86%and 32.97%,respectively.The number of effective patients at 3,6,12,18 and 24 months after ablation were 81,69,51,40 and 31 cases,and the average uterine volumes were(161.78±75.03)cm3,(168.50±84.77)cm3,(177.44±94.89)cm3,(177.73±84.02)cm3 and(188.89±90.47)cm3,respectively.During the follow-up period,6 patients were found to be pregnant.The recurrent rates at 6,12,18 and 24 months after ablation were 13.18%,32.61%,45.05%and 54.35%,respectively.Conclusion HIFU ablation is safe and effective for patients with recurrent adenomyosis.Although the long-term recurrence rate is relatively high,it remains a viable treatment option for young patients who wish to preserve their uterus.