Deep brain tumor refers to the tumor growing in the deep structure of the third ventricle,pineal region,sella region and so on,which is adjacent to important nerve and vascular structures.The operation is difficult and postoperative complications are frequent,and its treatment is usually based on surgery and combined with radiotherapy and chemotherapy.Ultrasound can not only be used to identify the size,shape,location and depth of the tumor,help physicians locate and remove the tumor more accurately,reduce the trauma and injury of surgery,but also assist tumor therapy drugs to cross the blood-brain barrier into the targeted site,or even directly ablate the tumor.This article mainly reviews the auxiliary role of ultrasound in the treatment of deep brain tumor from the aspects of non-surgical application and surgical application.