Objective To investigate the clinical application value of ultrasound-derived fat fraction(UDFF)in the quantitative assessment of hepatic steatosis in obese population.Methods A total of 70 obese patients with fatty liver confirmed by pathological results of liver tissue in our hospital were selected,including 25 cases of S1 grade(S1 grade group),20 cases of S2 grade(S2 grade group),and 25 cases of S3 grade(S3 grade group).The depth from the skin to the center of the region of interest and UDFF value were obtained by ultrasound,and the differences were compared.Two physicians independently measured the UDFF value,and the median values were recorded for inter-operator consistency analysis.The correlation between UDFF value and pathological grading,clinical data and measurement depth was analyzed.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of UDFF value for different degrees of hepatic steatosis.Results The UDFF value in S1,S2,and S3 grade groups were 17.08%±7.15%,24.80%±5.22%,and 28.48%±5.22%,respectively.And the differences was statistically significant(P＜0.05).There was no significant difference in measurement depth among the groups.The inter-operator intraclass correlation coefficients for the measurement of UDFF value in S1,S2,and S3 groups were 0.809,0.777,and 0.759,respectively(all P＜0.01),indicating good consistency.Correlation analysis showed that the UDFF value was moderately positively correlated with the pathological grading and measurement depth(r=0.638,0.313,both P＜0.01),while weakly positively correlated with body mass index and waist circumference(r=0.236,0.248,both P＜0.05).ROC curve analysis showed that the area under curve of UDFF value in diagnosing≥S2 and≥S3 grade hepatic steatosis were 0.86,0.82,with sensitivities of 91.1%,88.0%,and specificities of 72.0%and 68.9%,respectively.Conclusion UDFF has good clinical application value in the quantitative assessmemt of hepatic steatosis in obese population.
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