Objective To investigate the clinical application value of color Doppler ultrasound in the diagnosis of uterine sarcoma.Methods A total of 40 patients pathologically confirmed with uterine sarcoma and 50 patients pathologically confirmed with uterine fibroids in the department of obstetrics and gynecology of the Second Affiliated Hospital of Army Military Medical University were randomly selected.The clinical data and ultrasonographic characteristics were retrospectively analyzed.Results ① The onset age,proportion of menopausal individuals and CA125 increasing in patients with uterine sarcoma were higher than those in patients with uterine fibroids,the differences were statistically significant(both P<0.05).② There were significant differences in the number of lesions,maximum diameter,boundary,capsule,shape,internal echo,distribution site,blood flow distribution and blood flow grade between uterine sarcoma and uterine fibroids(all P<0.05).③ Among 40 patients with uterine sarcoma,23 cases were diagnosed with uterine tumors(possibly malignant)by preoperative ultrasound,including 1 case of uterine sarcoma,and the remaining 17 cases were as follows:9 cases of uterine fibroids(2 cases with possible degeneration),4 cases of endometrial cancer,1 case of uterine sarcoma,1 case of cervical cancer,1 case of angiomyxoma,and 1 case of vascular leiomyoma.Conclusion Color Doppler ultrasound has a certain clinical application value in the diagnosis of uterine sarcoma.