Efficacy of Conbercept combined with retinal laser photocoagulation in the treatment of branch retinal vein occlusion and macular edema by ultrasound evaluation
Objective To evaluate the efficacy of intravitreal injection of Conbercept combined with retinal laser photocoagulation in the treatment of patients with branch retinal vein occlusion(BRVO)and macular edema(ME)by ultrasound,and to explore its clinical value.Methods A total of 62 patients with BRVO and ME in our hospital were enrolle.According to random number table method,they were divided into photocoagulation group(31 cases,retinal laser photocoagulation)and Conbercept group(31 cases,intravitreal injection of Conbercept on the basis of retinal laser photocoagulation).All patients underwent ultrasound examination before and 8 weeks after treatment,then the ultrasound parameters[peak systolic velocity(PSV),end-diastolic velocity(EDV),resistance index(RI)]of central retinal artery(CRA)and ocular artery(OA),clinical curative effect,adverse reactions,best corrected visual acuity(BCVA)and central macular thickness(CMT)were compared between the two groups.The correlation between ultrasound parameters of CRA,OA and BCVA,CMT were analyzed by Pearson correlation analysis.Results Compared with the results in photocoagulation group after treatment,the BCVA,PSV,EDV and RI of CRA in Conbercept group were increased,while the CMT was decreased(all P<0.05).The curative effect in Conbercept group was higher than that in photocoagulation group(96.77％vs.80.65％,P<0.05).After treatment,there was no significant difference in the incidence of adverse reactions between Conbercept group and photocoagulation group(16.13％vs.29.03％).Pearson correlation analysis showed that the PSV,EDV,RI of CRA were positively correlated with BCVA,while negatively correlated with CMT(all P<0.05).Conclusion Intravitreal injection of Conbercept combined with retinal laser photocoagulation has significant clinical curative effect in patients with BRVO and ME.Ultrasound can accurately assess the efficacy and has a certain clinical value.
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