Study on the relationship between SNP of CD14 gene and allergic rhinitis in Xinjiang Uygurs and Hans
Objectives This study aimed to investigate the relationship between CD14 gene rs2569192(C/G) , rs3138078( -1359G/T) and allergic rhinitis (AR) in Xinjiang Uygur and Han populations as well as to determine characteristics of polymorphisms. Method: A total of 300 AR and 300 healthy controls subjects were included. The frequencies of genotypes and alleles were detected as well as the levels of tIgE in different genetypes were compared. Result:①The distribution of genotypes or alleles of CD14 gene rs2569192 (C/G), rs3138078 (-1359G/T) had no differences between the Xinjiang Uygurs and Hans(P>0, 05). The highest frequency of alleles was C. G. ②The frequencies of genotypes and alleles were not different between the AR and control group in Uygur and Han (P>0. 05). The frequencies of genotypes and alleles of rs2569192 were different between the Uygur AR and Han AR group(P<0. 05). ③The distribution of genotype frequencies and allele of rs 2569192 in the Xinjiang Uygur and Han population were quite different from Chinese Beijing Han populations. Japanese, European and African (P<0. 05). ④The serum total IgE level in AR group was higher than that in healthy control group(P<0. 05). Conclusion:①rs2569192(C/G),rs3138078(-1359G/T) polymorphisms were not different between the Chinese Xinjiang Uygur and Han population. The major allele were both C and G. Rs2569192 of CD14 in Xinjiang popula-tions was different from that in the other populations.②No relationship between rs2569192. Rs3138078 and AR was found. ③The serum total IgE level in AR group was higher than that in healthy control group. No relationship between CD14 two SNP and serum total IgE level was found.
NETL
NSTL
万方数据
维普
