Clinical analysis of endonasal endoscopic surgery in esthesioneuroblastoma
Objective:To investigate the clinical characteristics of esthesioneuroblastoma and the efficacy of en-donasal endoscopic surgery combined with radiotherapy/chemotherapy.Methods:The clinical and surgical data of 17 patients with esthesioneuroblastoma who underwent endonasal endoscopic surgery in our department from Sep-tember 2009 to June 2023 were retrospectively analyzed.Results:Among all patients,the modified Kadish stage B was identified in 4 patients,C in 10 patients,and D in 3 patients.Ten of them underwent endonasal endoscopic surgery without neck dissection in one day,whose average operation time is(5.2±2.5)hours and average blood loss is(192±162)mL.Skull base reconstructions were performed in 15 patients,postoperative complications were observed in 3 patients,and negative margins were obtained in 13 patients.All 17 patients were followed up for an average of(49.7±40.2)months.Three patients died and 6 had recurrence and/or metastasis.The 1-year,2-year and 5-year overall survival rates were 88.2％,80.2％,and 80.2％,respectively,and the 1-year,2-year and 5-year disease-free survival rates were 82.4％,82.4％,and 50.8％,respectively.The 2-year overall survival rates of patients with negative and positive margins were 100％and 25％,respectively,while the 2-year disease-free survival rates were 61.5％and 25.0％,respectively.Conclusion:Endonasal endoscopic surgery combined with radiotherapy/chemotherapy can achieve satisfactory effect in esthesioneuroblastoma,and the prognosis of pa-tients with positive margins is poor.
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