鼻腔鼻窦颅底孤立性纤维性肿瘤12例临床分析
Clinical analysis of 12 cases of solitary fibrous tumors in nasal cavity,sinuses and skull base
齐治宇 1于龙刚 1颜旭东 1王琳 1张雪琰 1李顺科 1吴策 1姜彦1
作者信息
- 1. 青岛大学附属医院耳鼻咽喉头颈外科/鼻颅底外科(山东青岛,266000)
- 折叠
摘要
目的:总结分析鼻腔鼻窦颅底孤立性纤维性肿瘤(solitary fibrous tumor,SFT)的临床表现、诊疗方法及预后特点.方法:回顾性分析青岛大学附属医院耳鼻咽喉头颈外科和颅底外科2014年4月-2022年1月收治的12例鼻腔鼻窦颅底SFT患者的临床资料,其中耳鼻咽喉头颈外科收治患者4例、颅底外科收治患者8例,分析其临床特点、诊疗经过及预后情况.患者均行手术治疗,其中4例术后辅助放化疗,8例未行放化疗.结果:术后随访12～60个月,4例术后辅助放化疗的患者均预后良好;8例未行放化疗患者中6例预后良好,另2例复发;4例患者既往有SFT手术史,复发后收治于青岛大学附属医院治疗,其中1例术后复发.所有患者均无转移.结论:鼻腔鼻窦颅底SFT较为罕见,对于该病最有效的治疗手段为手术切除,术后辅助放化疗及术后长期随访可以实现较好的预后.综合治疗中完整性手术切除肿瘤是治疗的关键.
Abstract
Objective:To summarize and analyze the clinical manifestations,diagnosis and management and prognostic features of solitary fibrous tumor(SFT)in nasal cavity,sinus and skull base.Methods:The clinical da-ta of 12 patients with STF from nasal cavity,sinus and cranial base admitted to the Affiliated Hospital of Qingdao University from April 2014 to January 2022 were retrospectively analyzed,including 4 patients admitted to the de-partment of Otolaryngology head and neck surgery and 8 patients admitted to the department of skull base surgery The clinical characteristics,diagnosis,management and prognosis were analyzed.Results:Twelve patients were included in this research,including 7 males and 5 females.All patients received surgical treatment,and 4 patients also received postoperative adjuvant chemoradiotherapy.After follow-up for 12-60 months,4 patients with adju-vant radiotherapy and chemotherapy had a good prognosis,and among 8 patients who did not receive radiotherapy and chemotherapy,6 patients had good prognosis and 2 patients showed relapse.Four patients with a history of recurrence of SFT after surgery were admitted to our hospital for surgical treatment,in which 1 patient had re-lapse after surgery,and none had metastasis.Nasal cavity and sinus to skull base SFT is rare.The most effective treatment for this disease is surgical resection,and postoperative adjuvant chemoradiation and long-term follow-up can achieve a better prognosis.En bloc resection is the key to treatment success.
关键词
鼻腔鼻窦肿瘤/颅底肿瘤/孤立性纤维性肿瘤Key words
nasal and sinus tumors/basicranial tumor/solitary fibrous tumor引用本文复制引用
基金项目
山东省自然科学基金(ZR2023MH027)
出版年
2024
NETL
NSTL
万方数据