Glucocorticoids(GC)are widely used in the clinical treatment of autoimmune inner ear diseases,sudden sensorineural hearing loss,Meniere's disease,sinusitis and other otolaryngology diseases.However,GC resistance remains a major factor contributing to the poor efficacy of clinical treatments.The mechanism of GC re-sistance is still unclear.This paper reviews the related mechanisms of GC resistance from the perspectives of GC receptor factors and non-GC receptor factors.Additionally,it summarizes the latest research progress on GC re-sistance in otolaryngological diseases,with the aim of identifying effective clinical alternative treatment options for reversing GC resistance in the future.
维普
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