记忆T细胞与变应性鼻炎发病机制的研究进展
Research progress of memory T cells in the pathogenesis of allergic rhinitis
高雅玟 1龙波锦 1余少卿1
作者信息
- 1. 同济大学附属同济医院耳鼻咽喉头颈外科(上海,200065)
- 折叠
摘要
变应性鼻炎(AR)是特应性个体暴露于过敏原后主要由免疫球蛋白E(IgE)介导的鼻黏膜非感染性慢性炎性疾病,T细胞是其中的核心细胞群.近年来,研究表明记忆T细胞在AR发病的发生发展中发挥着重要作用.本文就记忆T细胞在AR中的发病机制进行综述,以期进一步完善AR的发病机制,为后续临床上药物治疗提供理论依据和参考.
Abstract
Objective:Allergic rhinitis(AR)is a non-infectious chronic inflammatory disease of the nasal mu-cosa mainly mediated by immunoglobulin E(IgE)in atopic individuals after exposure to allergens.T cells are the core cell population.In recent years,studies have shown that memory T cells play an important role in the devel-opment of allergic rhinitis.This article reviews the pathogenesis of memory T cells in allergic rhinitis,in order to further improve the pathogenesis of allergic rhinitis and provide theoretical basis and reference for subsequent clini-cal drug treatment.
关键词
记忆T细胞/变应性鼻炎/发病机制Key words
memory T cells/allergic rhinitis/pathogenesis mechanism引用本文复制引用
基金项目
科技部国家重点研发项目(2022YFC2504100)
上海市综合医院中西医结合专项(ZHYY-ZXYJHZX-202118)
市级医院新兴前沿联合攻关项目(SHDC12024126)
出版年
2024
NETL
NSTL
万方数据