Clinical analysis of endoscopic transnasal resection of skull base chondrosarcoma
Objective:To explore the surgical techniques and clinical outcomes of endoscopic transnasal approa-ches in the treatment of skull base chondrosarcomas.Methods:Data from patients diagnosed with skull base chon-drosarcomas and treated via endoscopic transnasal surgery at the Department of Otorhinolaryngology and Head and Neck Surgery,Xuanwu Hospital,Capital Medical University,from 2013 to 2022 were collected.This retro-spective study analyzed the patients'clinical presentations,histopathological grading,involved sites and extents,and complications following the endoscopic transnasal surgery.Disease-free survival rates were calculated using the Kaplan-Meier method.Results:Complete data from 31 patients showed that the primary tumor site was in the petroclival region in 27 cases(87％),and the anterior skull base in 4 cases(13％).Pathological grades were GradeⅠ(12 cases),Grade Ⅱ(16 cases),and Grade Ⅲ(3 cases).Total resection was achieved in 25 cases,with residual disease post-surgery in 6 cases.The average follow-up duration was 35.7 months(ranging from 6 to 120 months).Among those who achieved complete resection,recurrence occurred in 5 cases(5/25),with a five-year disease-free survival rate of 80％.Postoperative complications included transient abducens nerve palsy in 6 patients and cere-brospinal fluid rhinorrhea in 4 patients.There were no cases of death or permanent cranial nerve palsy.Total re-section rate(P=0.001)and involvement of the cerebellopontine angle and jugular foramen(P=0.037)were iden-tified as independent risk factors for residual disease and recurrence of chondrosarcoma.Conclusion:The endo-scopic transnasal approach is a safe and feasible treatment option for skull base chondrosarcomas.
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